The centre-back was dismissed against QPR, but the Bluebirds won their appeal against the decision and Purse is available.
However, boss Dave Jones will have a tough decision to make after Gabor Gyepes impressed having come off the bench to fill the gap left by Purse's dismissal.
Left-back Miguel Comminges was also sent off in the encounter and will serve a one-match ban, meaning former Palace man Mark Kennedy should step in.
Michael Chopra will make his first return to Ninian Park following his loan move from Sunderland, while fellow striker Ross McCormack is in a race against time to return from a hamstring problem.
Jay Bothroyd, however, remains sidelined with his own hamstring injury.
Crystal Palace goalkeeper Julian Speroni is expected to be fit for the trip to Wales.
The Argentinian suffered a groin injury at Coventry last weekend which prevented him from taking goal-kicks but boss Neil Warnock is confident he will be available at Ninian Park.
Warnock does not usually name a goalkeeper among his substitutes but Darryl Flahavan could get a rare outing on the bench in case Speroni's injury flares up.
Strikers Alan Lee and James Scowcroft are building up their fitness following hamstring injuries and will not be rushed back with on-loan Craig Beattie filling the breach in attack.
Midfielder Leandre Griffit is fit following a hamstring problem and young full-back Lee Hills has joined Colchester on a month's loan.
Sporting Life.